Pediatrics

Trametinib may become an alternative treatment to hematopoietic stem cell transplantation in patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML).

The indication is for the improvement of glycemic control in pediatric patients aged 10 and older with type 2 diabetes and comes after positive results from the phase 3 T2NOW clinical trial.

Parents and caregivers sometimes have concerns about their children receiving these injections, but researchers and experts assure that the FDA-approved biologic is safe and effective in young populations.

Polyarticular juvenile idiopathic arthritis is a form of arthritis that affects multiple joints at one time.

The authors noted that these networks have a significant role in intellectual ability, physical coordination, working memory, emotional processing, and overall mental health.

Approximately 40% of caregivers make dosing errors when administering liquid medication to children.

Evidence indicates that up to 25% of all prescriptions for children could be dosed inappropriately, making it the most common type of medication administration error.

Patients with sickle cell disease with more than a 6-month delay transitioning from pediatric to adult care were about twice as likely to be hospitalized.

The treatment is the first liquid non-stimulant for attention deficit hyperactivity disorder to be approved in the United States.

Researchers aimed to explore impacts of omega-3 fatty acids on children’s behavior, mood, and sleep.

The findings demonstrated that daytime heat waves were associated with approximately 19% higher odds of asthma-related hospitalizations in children.

The incident highlights the benefits of out-of-court settlements in civil cases

The study data demonstrate that higher adiposity in childhood results in less dense breast tissue forming, reducing the risk of breast cancer.

Antihemophilic factor (recombinant) Fc-VWF-XTEN fusion protein-ehtl was initally approved in February 2023 for adults and children with hemophilia A for prophylaxis and on-demand treatment to control bleeding.

The data were previously presented at the Multilateral Initiative on Malaria 8th Pan-African Malaria Conference and have been submitted for regulatory review.

SMART uses an ICS and a long-acting beta-2 agonist (LABA) product, giving patients 4 years and older with moderate to severe uncontrolled persistent asthma 1 inhaler for dual symptom relief.

The vaccine protected against serotypes 19A and 19F, but statistical significance was not reached for serotype 3.

With these findings contributing to the understanding of neighborhood-level asthma risks, the authors note next steps can involve identifying and addressing disparities.

The results reinforce other real-world evidence from several broad infant immunization programs in the US, Spain, and France.

The acceptance is based on positive data from the phase 3 ADORING 1 and ADORING 2 pivotal trials, as well as interim results from the phase 3 ADORING 3 open-label, long-term extension trial.

Retail sales were associated with lower e-cigarette use, although recreational legalization also increased the frequency of cannabis use among adolescents.

The indication is for patients aged 12 years of age and older, and the treatment is intended to increase the number of mature neutrophils and lymphocytes in patients.

This approval makes lutetium Lu177 the first therapy to be approved for the treatment of gastroenteropancreatic neuroendocrine tumors in pediatric patients.

The treatment is indicated for adolescents at least 12 years of age who weigh at least 25 kg without a previous treatment history of antiretroviral therapies.

Pediatric patients with the variant were approximately 1.44 times more likely develop ALL compared with children who do not have the variant.

The authors believe that pancreatic enzyme therapy has potential in managing patient symptoms, altering the disease course, and the development of standardized care.

The FDA recommends the dosage of givinostat (Duvyzat; Italfarmaco, ITF Therapeutics) should be based on the individual’s body weight and administered twice daily with food.

Rilpivirine (Edurant Ped; Johnson and Johnson) is indicated for the treatment of HIV in combination with other antiretroviral therapies in treatment-naïve pediatric patients.

Regardless, hygiene practices and prevention measures for SARS-CoV-2 should be strongly practiced to prevent all respiratory viruses.

To date, this is the only targeted therapy indicated for the treatment of generalized pustular psoriasis.